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Smaller doses havebeen shown to be less effective (Konishi et al.1988; Halliday et al. The primary way this regulation is accomplished isthrough interaction with Mdm2 [ 26]. As mentioned previously, this apoptoticpathway will be discussed in detail in the second half of this chapter

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From studies of other species, however, it isknown that basophils have scatteredvesicles in their cytoplasmthat contain either a- or (3-endorphin (a morphine-relatedcompound).

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